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KMID : 0604520150410020135
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Journal of the Society of Cosmetic Scientists of Korea
2015 Volume.41 No. 2 p.135 ~ p.141
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Suppression of Cellular Senescence by Cordycepin in Replicative Aged Human Dermal Fibroblasts
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Kim Hyo-Jin
Lee So-Young
Kim Do-Hyoung
Jin Mu-Hyun
Roh Seok-Sun
Kim Hyung-Min
Choi In-Hwa
Lee Myeong-Soo
Lee Sang-Hwa
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Abstract
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Cell senescence can be identified by cellular changes that occur as a result of intrinsic aging and/or diseases. In case of skin cells, aging and cell senescence caused by external factors results in cessation of cell proliferation and cellular malfunction, which, in turn, accelerates skin aging. In this study, inhibition of cell senescence and enhancement of cell function were studied using cordycepin to evaluate the potential for skin anti-aging agent. By comparing with the number of senescence associated with β-galactosidase (SA-β-gal) positive cells in young and replicative aged human fibroblasts, it was found that replicative aged cells showed higher expression of β-galactosidase. Treatment of cordycepin ? known as an anti-oxidative and anti-inflammatory agent ? reduced β-galactosidase expression in senescent cells and enhanced cell survival in serum-free culture condition. Cordycepin also showed superb inhibition of ROS, which is another indicator of cell senescence. The results of this study proved the anti-aging effect of cordycepin on human fibroblasts and also proposed a possibility of its use as an anti-aging cosmetic ingredient.
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KEYWORD
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anti-aging, cordycepin, cell senescence, dermal fibroblasts, β-galactosidase
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